{"id":2080,"date":"2025-11-08T11:30:56","date_gmt":"2025-11-08T03:30:56","guid":{"rendered":"https:\/\/www.amigoskingdom.com\/magazine\/?p=2080"},"modified":"2025-11-08T00:33:54","modified_gmt":"2025-11-07T16:33:54","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e9%9d%a9%e5%91%bd%ef%bc%9a%e5%b9%b9%e7%b4%b0%e8%83%9e%e7%99%82%e6%b3%95%e6%93%ba%e8%84%ab%e8%83%b0%e5%b3%b6%e7%b4%a0%e9%87%9d%e9%a0%ad","status":"publish","type":"post","link":"https:\/\/www.amigoskingdom.com\/magazine\/2025\/11\/08\/%e7%b3%96%e5%b0%bf%e7%97%85%e9%9d%a9%e5%91%bd%ef%bc%9a%e5%b9%b9%e7%b4%b0%e8%83%9e%e7%99%82%e6%b3%95%e6%93%ba%e8%84%ab%e8%83%b0%e5%b3%b6%e7%b4%a0%e9%87%9d%e9%a0%ad\/","title":{"rendered":"\u7cd6\u5c3f\u75c5\u9769\u547d\u4f86\u4e86\uff012025\u5e74\u6700\u65b0\u5e79\u7d30\u80de\u7642\u6cd5\uff0c\u8b931\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u64fa\u812b\u91dd\u982d\u7684\u5e0c\u671b"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<h4 class=\"wp-block-heading\">\u5f15\u8a00\uff1a\u7cd6\u5c3f\u75c5\u4e0d\u518d\u662f\u7d42\u8eab\u67b7\u9396<\/h4>\n<\/blockquote>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\uff0c\u9019\u500b\u5f71\u97ff\u5168\u7403\u8d85\u904e5\u5104\u4eba\u7684\u6162\u6027\u75be\u75c5\uff0c\u9577\u671f\u4ee5\u4f86\u88ab\u8996\u70ba\u300c\u7121\u6cd5\u6839\u6cbb\u300d\u7684\u9811\u75be\u3002\u7121\u8ad6\u662f1\u578b\u7cd6\u5c3f\u75c5\uff08Type 1 Diabetes, T1D\uff09\u9084\u662f2\u578b\u7cd6\u5c3f\u75c5\uff08Type 2 Diabetes, T2D\uff09\uff0c\u60a3\u8005\u6bcf\u5929\u9762\u5c0d\u8840\u7cd6\u76e3\u6e2c\u3001\u80f0\u5cf6\u7d20\u6ce8\u5c04\u3001\u98f2\u98df\u8a08\u7b97\u7684\u58d3\u529b\uff0c\u534a\u591c\u9a5a\u9192\u6015\u4f4e\u8840\u7cd6\u7684\u6050\u61fc\uff0c\u66f4\u662f\u5bb6\u5e38\u4fbf\u98ef\u3002\u6839\u64da\u570b\u969b\u7cd6\u5c3f\u75c5\u806f\u76df\uff08IDF\uff09\u6578\u64da\uff0c\u9810\u8a08\u52302040\u5e74\uff0c\u5168\u7403\u7cd6\u5c3f\u75c5\u60a3\u8005\u5c07\u589e\u81f37.8\u5104\u4eba\uff0c\u5176\u4e2d1\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5c07\u5f9e840\u842c\u4eba\u589e\u81f31500-1700\u842c\u4eba\u3002\u4f462025\u5e74\uff0c\u79d1\u5b78\u754c\u5e36\u4f86\u9707\u64bc\u6027\u7a81\u7834\uff1a<strong>\u5e79\u7d30\u80de\u7642\u6cd5<\/strong>\uff08Stem Cell Therapy for Diabetes\uff09\u6b63\u91cd\u5851\u7cd6\u5c3f\u75c5\u6cbb\u7642\u683c\u5c40\uff0c\u8b93\u300c\u80f0\u5cf6\u7d20\u7368\u7acb\u300d\uff08Insulin Independence\uff09\u4e0d\u518d\u662f\u9059\u4e0d\u53ef\u53ca\u7684\u5922\u60f3\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-1024x683.jpg\" alt=\"\u4e16\u754c\u7cd6\u5c3f\u75c5\u65e5 - Nov 14\" class=\"wp-image-2082 lazyload\" data-srcset=\"https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-1024x683.jpg 1024w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-300x200.jpg 300w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-768x512.jpg 768w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-1536x1024.jpg 1536w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-2048x1365.jpg 2048w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-150x100.jpg 150w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-330x220.jpg 330w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-420x280.jpg 420w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/72531739_9695309-510x340.jpg 510w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><\/figure>\n\n\n\n<p>\u60f3\u50cf\u4e00\u4e0b\uff0c\u4e00\u6b21\u55ae\u6b21\u8f38\u6ce8\uff0c\u5c31\u80fd\u8b93\u8eab\u9ad4\u300c\u81ea\u5df1\u88fd\u9020\u80f0\u5cf6\u7d20\u300d\uff0c\u8840\u7cd6\u81ea\u52d5\u7a69\u5b9a\uff0c\u56b4\u91cd\u4f4e\u8840\u7cd6\u4e8b\u4ef6\uff08Severe Hypoglycemic Events, SHEs\uff09\u5fb9\u5e95\u6d88\u5931\u3002\u9019\u4e0d\u662f\u79d1\u5e7b\uff0c\u800c\u662fVertex Pharmaceuticals\u7684<strong>VX-880<\/strong>\uff08\u73fe\u66f4\u540dzimislecel\uff09\u5728\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u671f\u520a\u300b\uff08NEJM\uff09<strong>2025\u5e746\u670820\u65e5<\/strong>\u767c\u8868\u7684\u7814\u7a76\u771f\u5be6\u6210\u679c\u3002\u9019\u9805\u7642\u6cd5\u91dd\u5c0d1\u578b\u7cd6\u5c3f\u75c5\u9ad8\u98a8\u96aa\u60a3\u8005\uff0c\u900f\u904e\u5be6\u9a57\u5ba4\u57f9\u990a\u7684\u5b8c\u5168\u5206\u5316\u80f0\u5cf6\u7d30\u80de\uff08Fully Differentiated Islet Cells\uff09\uff0c\u6062\u5fa9\u751f\u7406\u80f0\u5cf6\u529f\u80fd\u3002\u9999\u6e2f\u4f5c\u70ba\u4e9e\u6d32\u7cd6\u5c3f\u75c5\u9ad8\u767c\u5340\uff0c1\u578b\u7cd6\u5c3f\u75c5\u96d6\u50c5\u4f54\u7e3d\u657810%\uff0c\u4f46\u5e74\u8f15\u60a3\u8005\u6bd4\u4f8b\u9ad8\uff0c\u91ab\u7642\u8ca0\u64d4\u6c89\u91cd\u2014\u2014\u82e5\u6b64\u7642\u6cd5\u666e\u53ca\uff0c\u5c07\u70ba\u6578\u842c\u9999\u6e2f\u5bb6\u5ead\u5e36\u4f86\u65b0\u751f\u3002<\/p>\n\n\n\n<p>\u672c\u6587\u5c07\u6df1\u5165\u6dfa\u51fa\u89e3\u91cb\u7cd6\u5c3f\u75c5\u6700\u65b0\u6cbb\u7642\u767c\u5c55\uff0c\u805a\u71262025\u5e74\u8fd1\u534a\u5e74\u79d1\u7814\u65b0\u805e\u8207\u81e8\u5e8a\u8a66\u9a57\uff0c\u5e6b\u52a9\u8b80\u8005\u4e86\u89e3<strong>\u518d\u751f\u91ab\u5b78<\/strong>\uff08Regenerative Medicine in Diabetes\uff09\u5982\u4f55\u958b\u555f\u300c\u529f\u80fd\u6027\u6cbb\u7652\u300d\uff08Functional Cure\uff09\u6642\u4ee3\u3002\u7121\u8ad6\u4f60\u662f\u60a3\u8005\u3001\u5bb6\u5c6c\uff0c\u9084\u662f\u5c0d<strong>\u7cd6\u5c3f\u75c5\u5e79\u7d30\u80de\u7642\u6cd5<\/strong>\u611f\u8208\u8da3\u7684\u8b80\u8005\uff0c\u9019\u7bc7\u6307\u5357\u5c07\u63d0\u4f9b\u5be6\u7528\u6d1e\u898b\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u7cd6\u5c3f\u75c5\u57fa\u790e\u77e5\u8b58\uff1a\u70ba\u4f55\u6cbb\u7642\u5982\u6b64\u8271\u96e3\uff1f<\/h4>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u6838\u5fc3\u554f\u984c\u662f\u80f0\u81df\u03b2\u7d30\u80de\uff08Beta Cells\uff09\u7121\u6cd5\u7522\u751f\u8db3\u5920\u80f0\u5cf6\u7d20\uff08Insulin\uff09\uff0c\u5c0e\u81f4\u8840\u7cd6\u5931\u63a7\u30021\u578b\u7cd6\u5c3f\u75c5\u662f\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\uff0c\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u03b2\u7d30\u80de\uff0c\u60a3\u8005\u9700\u7d42\u751f\u4f9d\u8cf4\u5916\u6e90\u80f0\u5cf6\u7d20\uff1b2\u578b\u7cd6\u5c3f\u75c5\u5247\u8207\u80f0\u5cf6\u7d20\u62b5\u6297\uff08Insulin Resistance\uff09\u76f8\u95dc\uff0c\u5e38\u898b\u65bc\u80a5\u80d6\u6216\u907a\u50b3\u56e0\u7d20\u3002<\/p>\n\n\n\n<div class=\"wp-block-cover\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\"><\/span><img decoding=\"async\" width=\"1000\" height=\"665\" class=\"wp-block-cover__image-background wp-image-2083 lazyload\" alt=\"\u60a3\u8005\u9700\u7d42\u751f\u4f9d\u8cf4\u5916\u6e90\u80f0\u5cf6\u7d20\" data-src=\"https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/135687.jpg\" data-object-fit=\"cover\" data-srcset=\"https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/135687.jpg 1000w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/135687-300x200.jpg 300w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/135687-768x511.jpg 768w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/135687-150x100.jpg 150w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/135687-330x220.jpg 330w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/135687-420x280.jpg 420w, https:\/\/www.amigoskingdom.com\/magazine\/wp-content\/uploads\/2025\/11\/135687-510x340.jpg 510w\" data-sizes=\"(max-width: 1000px) 100vw, 1000px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1000px; --smush-placeholder-aspect-ratio: 1000\/665;\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size\">1\u578b\u7cd6\u5c3f\u75c5\u662f\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\uff0c<\/p>\n\n\n\n<p class=\"has-text-align-center has-large-font-size\">\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u03b2\u7d30\u80de\uff0c<\/p>\n\n\n\n<p class=\"has-text-align-center has-large-font-size\">\u60a3\u8005\u9700\u7d42\u751f\u4f9d\u8cf4\u5916\u6e90\u80f0\u5cf6\u7d20<\/p>\n<\/div><\/div>\n\n\n\n<p>\u50b3\u7d71\u6cbb\u7642\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u751f\u6d3b\u7ba1\u7406<\/strong>\uff1a\u4f4eGI\u98f2\u98df\u3001\u904b\u52d5\u3001\u8840\u7cd6\u76e3\u6e2c\u3002<\/li>\n\n\n\n<li><strong>\u85e5\u7269\u8207\u88dd\u7f6e<\/strong>\uff1a\u53e3\u670d\u85e5\u5982Metformin\uff0c\u80f0\u5cf6\u7d20\u6cf5\uff08Insulin Pump\uff09\uff0c\u9023\u7e8c\u8840\u7cd6\u76e3\u6e2c\u7cfb\u7d71\uff08Continuous Glucose Monitoring, CGM\uff09\u3002<\/li>\n\n\n\n<li><strong>\u4f75\u767c\u75c7\u9810\u9632<\/strong>\uff1a\u63a7\u5236HbA1c\uff08\u7cd6\u5316\u8840\u7d05\u86cb\u767d\uff09&lt;7%\uff0c\u907f\u514d\u5fc3\u8840\u7ba1\u75c5\u3001\u814e\u8870\u7aed\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4f46\u9019\u4e9b\u50c5\u300c\u6cbb\u6a19\u300d\uff0c\u7121\u6cd5\u4fee\u5fa9\u03b2\u7d30\u80de\u640d\u5931\u30022025\u5e74\uff0c<strong>\u03b2\u7d30\u80de\u518d\u751f<\/strong>\uff08Beta Cell Regeneration\uff09\u6210\u70ba\u71b1\u9ede\uff0c\u79d1\u5b78\u5bb6\u900f\u904e\u5e79\u7d30\u80de\u6280\u8853\u300c\u91cd\u555f\u80f0\u5cf6\u5de5\u5ee0\u300d\uff0c\u8b93\u8eab\u9ad4\u81ea\u884c\u7522\u751f\u80f0\u5cf6\u7d20\u3002\u9019\u4e0d\u50c5\u964d\u4f4e\u4f4e\u8840\u7cd6\u98a8\u96aa\uff0c\u9084\u6539\u5584\u751f\u6d3b\u54c1\u8cea\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2025\u5e74\u6700\u5927\u4eae\u9ede\uff1aVX-880\u5e79\u7d30\u80de\u7642\u6cd5\uff0c\u5168\u7403\u9996\u500b\u80f0\u5cf6\u7d30\u80de\u79fb\u690d\u6210\u529f\u6848\u4f8b<\/h4>\n\n\n\n<p>Vertex Pharmaceuticals\u7684VX-880\u662f2025\u5e74\u7cd6\u5c3f\u75c5\u6cbb\u7642\u7684\u660e\u661f\u9805\u76ee\u3002\u9019\u9805\u7642\u6cd5\u4f7f\u7528\u591a\u80fd\u5e79\u7d30\u80de\uff08Pluripotent Stem Cells\uff09\u57f9\u990a\u51fa\u529f\u80fd\u5b8c\u6574\u7684\u80f0\u5cf6\u7d30\u80de\uff0c<strong>\u8f38\u6ce8\u81f3\u60a3\u8005\u809d\u9580\u975c\u8108\uff08Hepatic Portal Vein\uff09<\/strong>\uff0c\u8b93\u5176\u5728\u9ad4\u5167\u5b9a\u6b96\u4e26\u5206\u6ccc\u80f0\u5cf6\u7d20\u3002<strong>\u9700\u642d\u914d\u6a19\u6e96\u514d\u75ab\u6291\u5236\u5291\uff08\u5982Tacrolimus\uff09\u9632\u6392\u65a5<\/strong>\uff0c\u4e26\u975e\u300c\u96b1\u5f62\u7d30\u80de\u300d\u6280\u8853\u3002<\/p>\n\n\n\n<p>\u6839\u64daNEJM <strong>2025\u5e746\u670820\u65e5<\/strong>\u767c\u8868\u7684\u7814\u7a76\uff08DOI: 10.1056\/NEJMoa2506549\uff09\uff0cPhase 1\/2\u8a66\u9a57\uff08FORWARD-101, NCT04786262\uff09\u62db\u52df12\u540d\u7f79\u60a31\u578b\u7cd6\u5c3f\u75c530\u5e74\u4ee5\u4e0a\u7684\u60a3\u8005\uff0c\u57fa\u7ddaC-\u80bd\uff08C-Peptide\uff0c\u5167\u751f\u80f0\u5cf6\u7d20\u6307\u6a19\uff09\u4e0d\u53ef\u5075\u6e2c\uff0c\u6bcf\u5929\u9700\u7d0439.3\u55ae\u4f4d\u80f0\u5cf6\u7d20\u3002\u7d50\u679c\u4ee4\u4eba\u632f\u596e\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7b2c90\u5929<\/strong>\uff1a100%\u60a3\u8005\u80f0\u5cf6\u7d30\u80de\u5b9a\u6b96\uff0c\u8461\u8404\u7cd6\u97ff\u61c9\u6027\u80f0\u5cf6\u7d20\u7522\u751f\u3002<\/li>\n\n\n\n<li><strong>1\u5e74\u8ffd\u8e64<\/strong>\uff1a\u6240\u670912\u540d\u60a3\u8005HbA1c&lt;7%\u3001\u6642\u9593\u5728\u7bc4\u570d\u5167\uff08Time in Range, TIR\uff09>70%\uff0c\u56b4\u91cd\u4f4e\u8840\u7cd6\u4e8b\u4ef6\u5b8c\u5168\u6d88\u9664\u3002\u5916\u6e90\u80f0\u5cf6\u7d20\u7528\u91cf\u5e73\u5747\u4e0b\u964d92%\uff0c<strong>10\u540d\u60a3\u8005\u9054\u80f0\u5cf6\u7d20\u7368\u7acb<\/strong>\u3002<\/li>\n\n\n\n<li><strong>\u5b89\u5168\u6027<\/strong>\uff1a\u7121VX-880\u76f8\u95dc\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08Serious Adverse Events\uff09\uff0c\u526f\u4f5c\u7528\u4e3b\u8981\u4f86\u81ea\u514d\u75ab\u6291\u5236\uff08\u5982\u8f15\u5fae\u611f\u67d3\uff09\uff0c\u5169\u4f8b\u6b7b\u4ea1\u8207\u7642\u6cd5\u7121\u95dc\u3002<\/li>\n<\/ul>\n\n\n\n<p>ADA 2025\u5e746\u6708\u6703\u8b70\u4e0a\uff0c\u7814\u7a76\u8005Michael R. Rickels\u91ab\u5e2b\u5f37\u8abf\uff1a\u300c\u9019\u662f1\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u7684\u8f49\u6298\u9ede\uff0c\u5f9e\u75c7\u72c0\u7ba1\u7406\u9081\u5411\u529f\u80fd\u6062\u5fa9\u3002\u300dEASD 2025\u5e749\u6708\u7dad\u4e5f\u7d0d\u6703\u8b70\u9032\u4e00\u6b65\u516c\u5e031\u5e74\u6578\u64da\uff1aHbA1c\u5f9e7.8%\u964d\u81f36.0%\u300183%\u80f0\u5cf6\u7d20\u7368\u7acb\u3001SHEs\u6d88\u9664\uff0c\u78ba\u8a8d\u8010\u4e45\u6027\u3002<\/p>\n\n\n\n<p>Vertex\u9810\u8a08Phase 3\u8a66\u9a57<strong>2025\u4e0a\u534a\u5e74\u5b8c\u6210\u62db\u52df50\u4eba<\/strong>\uff0c2026\u5e74\u63d0\u4ea4\u5168\u7403\u76e3\u7ba1\u7533\u8acb\uff08FDA\/EMA\uff09\u3002\u9999\u6e2f\u60a3\u8005\u53ef\u671b\u900f\u904e\u570b\u969b\u8a66\u9a57\u6216\u672a\u4f86\u5546\u696d\u5316\u53d7\u76ca\uff0c\u5c24\u5176\u91dd\u5c0d\u4f4e\u8840\u7cd6\u7121\u89ba\u5bdf\uff08Hypoglycemic Unawareness\uff09\u7684\u9ad8\u98a8\u96aa\u7fa4\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u5c08\u5bb6\u89c0\u9ede\uff1aDr. Laura Alonso\u5982\u4f55\u770b\u5f85\u03b2\u7d30\u80de\u518d\u751f\uff1f<\/h4>\n\n\n\n<p>Weill Cornell\u91ab\u5b78\u9662\u5167\u5206\u6ccc\u4e3b\u4efbDr. Laura C. Alonso\u662f\u03b2\u7d30\u80de\u518d\u751f\u9818\u57df\u6b0a\u5a01\u3002\u5979\u7684\u7814\u7a76\u805a\u7126\u80f0\u81df\u5982\u4f55\u8abf\u63a7\u03b2\u7d30\u80de\u6578\u91cf\uff0c\u76ee\u6a19\u662f\u523a\u6fc0\u5167\u751f\u518d\u751f\u4ee5\u6cbb\u7642\u7cd6\u5c3f\u75c5\u3002\u96d6\u7136\u7121\u76f4\u63a5ADA 2025 VX-880\u5f15\u8ff0\uff0c\u4f46\u5176\u9577\u671f\u89c0\u9ede\u652f\u6301\u6b64\u985e\u7642\u6cd5\uff1a\u300c\u5f9e\u63a7\u5236\u75c7\u72c0\u5230\u6062\u5fa9\u529f\u80fd\uff0c\u9019\u662f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u7684\u5de8\u5927\u8e8d\u9032\u3002\u5e79\u7d30\u80de\u6280\u8853\u8b49\u660e\u53ef\u91cd\u5851\u751f\u7406\u80f0\u5cf6\u529f\u80fd\uff0c\u4f46\u9700\u89e3\u6c7a\u9577\u671f\u8010\u4e45\u6027\u8207\u514d\u75ab\u6311\u6230\u3002\u300d<\/p>\n\n\n\n<p>Alonso\u5f37\u8abf\uff0c\u9999\u6e2f\u7b49\u4e9e\u6d32\u5730\u53401\u578b\u7cd6\u5c3f\u75c5\u5e74\u9f61\u504f\u4f4e\u3001\u75c5\u7a0b\u9577\uff0c\u91ab\u7642\u6210\u672c\u9ad8\u3002\u518d\u751f\u7642\u6cd5\u82e5\u666e\u53ca\uff0c\u53ef\u6e1b\u8f15\u793e\u6703\u8ca0\u64d4\u3002\u5979\u9810\u6e2c\uff0c\u7d50\u5408AI\u8840\u7cd6\u9810\u6e2c\uff0c\u672a\u4f86\u60a3\u8005\u5c07\u4eab\u300c\u96f6\u91dd\u982d\u300d\u751f\u6d3b\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u5176\u4ed62025\u5e74\u8fd1\u534a\u5e74\u7a81\u7834\uff1a\u591a\u5143\u5316\u7cd6\u5c3f\u75c5\u6cbb\u7642\u767c\u5c55<\/h4>\n\n\n\n<p>VX-880\u4e0d\u662f\u5b64\u4f8b\u30022025\u5e74\u4e0a\u534a\u5e74\uff0c\u591a\u9805\u79d1\u7814\u65b0\u805e\u9ede\u4eae\u5e0c\u671b\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u4e2d\u570b\u9996\u4f8b\u81ea\u9ad4\u5e79\u7d30\u80de\u6cbb\u76521\u578b\u7cd6\u5c3f\u75c5\uff082024\u5e74\u5ef6\u7e8c\u5831\u5c0e\uff09<\/strong>\uff1a\u5317\u4eac\u5927\u5b78\u9127\u5b8f\u9b41\u5718\u968a\u65bc<strong>2024\u5e749\u6708Cell\u671f\u520a<\/strong>\u5831\u5c0e\uff0c\u4f7f\u7528\u60a3\u8005\u81ea\u8eab\u7d30\u80de\u91cd\u7de8\u7a0b\u70ba\u5316\u5b78\u8a98\u5c0e\u591a\u80fd\u5e79\u7d30\u80de\uff08CiPSC\uff09\uff0c\u518d\u8f49\u5316\u70ba\u80f0\u5cf6\u7d30\u80de\u79fb\u690d\u3002\u4e00\u540d25\u6b72\u5973\u6027\u60a3\u8005\u6ce8\u5c04\u5f8c\uff0c75\u5929\u5167\u9054\u80f0\u5cf6\u7d20\u7368\u7acb\uff0c1\u5e74\u5f8c\u4ecd\u7a69\u5b9a\u3002\u6b64\u70ba\u5168\u7403\u9996\u4f8b\u81ea\u9ad4\u7642\u6cd5\uff0c\u907f\u958b\u6392\u65a5\u554f\u984c\uff0c\u9810\u8a082026\u5e74\u64f4\u5927\u8a66\u9a57\u3002<\/li>\n\n\n\n<li><strong>Sana Biotechnology\u7684UP421<\/strong>\uff1aADA 2025\u5c55\u793a6\u500b\u6708\u6578\u64da\uff0c\u6b64\u7642\u6cd5\u7528\u300chypoimmune\u80f0\u5cf6\u7d30\u80de\u300d\u898f\u907f\u514d\u75ab\u653b\u64ca\uff0c\u521d\u6b65\u8a66\u9a57\u986f\u793aC-\u80bd\u7a69\u5b9a\uff0c<strong>\u7121\u9700\u514d\u75ab\u6291\u5236<\/strong>\u3002<\/li>\n\n\n\n<li><strong>\u5eb7\u4e43\u723e\u5927\u5b78\u6c27\u5408\u690d\u5165\u7269<\/strong>\uff1a<strong>2025\u5e748\u6708Nature Communications<\/strong>\u767c\u8868\uff0c\u6b64\u690d\u5165\u7cfb\u7d71\u4f9b\u61c9\u6c27\u6c23\u7d66\u5bc6\u96c6\u80f0\u5cf6\u7d30\u80de\uff0c\u7121\u9700\u514d\u75ab\u85e5\uff0c\u9006\u8f49\u5c0f\u9f20\u7cd6\u5c3f\u75c5\uff0c\u9069\u7528\u6162\u6027\u75c5\u3002<\/li>\n\n\n\n<li><strong>\u54c8\u4f5bMelton\u5718\u968a\u9032\u5c55<\/strong>\uff1a<strong>2025\u5e746\u6708Harvard Gazette<\/strong>\u5831\u5c0e\uff0cSemma Therapeutics\uff082019\u5e74\u4f75\u5165Vertex\uff09\u79fb\u690d\u5e79\u7d30\u80de\u884d\u751f\u03b2\u7d30\u80de\uff0c<strong>\u8d85\u904e10\u540d\u60a3\u8005\u9054\u80f0\u5cf6\u7d20\u7368\u7acb<\/strong>\uff0c\u8b49\u660e\u53ef\u64f4\u5927\u751f\u7522\u3002<\/li>\n\n\n\n<li><strong>Weill Cornell\u8840\u7ba1\u5167\u76ae\u7d30\u80de\u8f14\u52a9\u79fb\u690d<\/strong>\uff1a<strong>2025\u5e742\u6708Science Advances<\/strong>\u7814\u7a76\uff0cR-VECs\uff08\u91cd\u7de8\u7a0b\u8840\u7ba1\u5167\u76ae\u7d30\u80de\uff09\u652f\u6301\u76ae\u4e0b\u80f0\u5cf6\u79fb\u690d\uff0c\u5c0f\u9f2020\u9031\u8840\u7cd6\u6b63\u5e38\uff0c\u5960\u57fa\u7121\u809d\u79fb\u690d\u7642\u6cd5\u57fa\u790e\u3002<\/li>\n\n\n\n<li><strong>Teplizumab\u5ef6\u7de9\u9032\u5c55<\/strong>\uff1a<strong>2025\u5e7410\u6708Scientific American<\/strong>\u66f4\u65b0\uff0c\u6b64\u85e5\u5ef6\u7de91\u578b\u7cd6\u5c3f\u75c5\u81e8\u5e8a\u767c\u75c5\u4e2d\u4f4d2\u5e74\uff0c\u70ba\u5e79\u7d30\u80de\u7642\u6cd5\u722d\u53d6\u6642\u9593\uff0c\u6a4b\u63a5\u300c\u5b8c\u6574\u6cbb\u7652\u300d\u3002<\/li>\n\n\n\n<li><strong>Lantidra\u80f0\u5cf6\u79fb\u690d<\/strong>\uff1a<strong>2025\u5e749\u6708UI Health<\/strong>\u9996\u4f8b\uff0c69\u6b72\u60a3\u8005\u63a5\u53d7\u7570\u9ad4\u80f0\u5cf6\u79fb\u690d\u5f8c\u505c\u7528\u80f0\u5cf6\u7d20\uff0c\u6a19\u8a8c\u5546\u696d\u5316\u91cc\u7a0b\u7891\u3002<\/li>\n\n\n\n<li><strong>Mount Sinai Harmine\u85e5\u7269<\/strong>\uff1a<strong>2025\u5e743\u6708Forbes<\/strong>\u5831\u5c0e\uff0c\u6b64\u5c0f\u5206\u5b50\u7d50\u5408GLP-1\u523a\u6fc0\u03b2\u7d30\u80de\u589e\u6b96\uff0c\u9069\u75281\/2\u578b\u7cd6\u5c3f\u75c5\uff0cPhase 1\u5b8c\u6210\uff0c<strong>Phase 2\u6578\u64da\u9810\u8a082026\u5e74<\/strong>\u3002<\/li>\n<\/ol>\n\n\n\n<p>\u9019\u4e9b\u7a81\u7834\u6db5\u84cb\u81ea\u9ad4\/\u7570\u9ad4\u79fb\u690d\u3001\u514d\u75ab\u898f\u907f\u3001\u85e5\u7269\u8f14\u52a9\uff0c\u9810\u8a082030\u5e74\u524d\uff0c\u9999\u6e2f\u7cd6\u5c3f\u75c5\u4e2d\u5fc3\uff08\u5982\u746a\u9e97\u91ab\u9662\uff09\u5c07\u5c0e\u5165\u591a\u9805\u7642\u6cd5\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u9999\u6e2f\u8996\u89d2\uff1a\u4e9e\u6d32\u7cd6\u5c3f\u75c5\u9ad8\u767c\uff0c\u6cbb\u7642\u767c\u5c55\u5982\u4f55\u53d7\u60e0\uff1f<\/h4>\n\n\n\n<p>\u9999\u6e2f\u7cd6\u5c3f\u75c5\u76db\u884c\u7387\u7d04<strong>8.5%-10.2%<\/strong>\uff082020-22\u4eba\u53e3\u5065\u5eb7\u8abf\u67e5\uff09\uff0c1\u578b\u60a3\u8005\u4f30\u8a08\u7d041\u842c\u4eba\uff0c\u5152\u7ae5\u767c\u75c5\u7387\u5448\u4e0a\u5347\u8da8\u52e2\u3002\u516c\u71df\u91ab\u7642\u63d0\u4f9b\u514d\u8cbb\u80f0\u5cf6\u7d20\uff0c\u4f46\u518d\u751f\u7642\u6cd5\u9700\u514d\u75ab\u85e5\uff0c\u6210\u672c\u9ad8\u3002VX-880\u82e5\u7372\u6279\uff0c\u9810\u8a08\u900f\u904e\u79c1\u71df\u6a5f\u69cb\uff08\u5982\u990a\u548c\u91ab\u9662\uff09\u5f15\u5165\uff0c\u521d\u671f\u9650\u9ad8\u98a8\u96aa\u60a3\u8005\u3002\u653f\u5e9c\u53ef\u501f\u93e1\u65b0\u52a0\u5761\uff0c\u8cc7\u52a9\u81e8\u5e8a\u8a66\u9a57\uff0c\u6e1b\u8f15\u516c\u71df\u8ca0\u64d4\u3002<\/p>\n\n\n\n<p>\u60a3\u8005\u6545\u4e8b\uff1a\u570b\u969b\u8a66\u9a57\u53c3\u8207\u8005\u56de\u994b\uff1a\u300c\u4e0d\u518d\u64d4\u5fc3\u534a\u591c\u4f4e\u8840\u7cd6\uff0c\u65c5\u884c\u7121\u6182\u3002\u300d\u9019\u662f\u7121\u6578\u4eba\u7684\u5beb\u7167\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u672a\u4f86\u5c55\u671b\uff1a\u5f9e\u8a66\u9a57\u5230\u5e38\u898f\u6cbb\u7642\u7684\u8def\u5f91<\/h4>\n\n\n\n<p>2025\u5e74\u662f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u7684\u5206\u6c34\u5dba\u3002<strong>Vertex VX-264\uff08\u7d30\u80de+\u88dd\u7f6e\uff09\u65bc2025\u5e743\u6708\u5ba3\u5e03Phase 1\/2 Day 90\u6578\u64da\u672a\u9054\u6a19\uff0c\u5df2\u505c\u6b62\u63a8\u9032<\/strong>\uff0c\u986f\u793a\u7121\u514d\u75ab\u6291\u5236\u8def\u5f91\u4ecd\u5145\u6eff\u6311\u6230\u3002\u7d50\u5408GLP-1\u85e5\u7269\uff08\u5982Semaglutide\uff09\uff0c2\u578b\u7cd6\u5c3f\u75c5\u518d\u751f\u7642\u6cd5\u5c07\u8ddf\u9032\u3002\u6311\u6230\u5305\u62ec\uff1a\u7d30\u80de\u58fd\u547d\uff08&gt;10\u5e74\uff09\u3001\u6210\u672c\uff08\u55ae\u6b21\u8f38\u6ce8\u4f3010\u842c\u7f8e\u5143\uff09\u3001\u516c\u5e73\u6027\u3002<\/p>\n\n\n\n<p>\u5c08\u5bb6\u547c\u7c72\uff1a\u7be9\u6aa2\uff08Screening for Type 1 Diabetes\uff09\u666e\u53ca\uff0c\u65e9\u671f\u4ecb\u5165teplizumab\u3002\u9999\u6e2f\u7cd6\u5c3f\u75c5\u5354\u6703\u53ef\u63a8\u5ee3\u6559\u80b2\uff0c\u52a0\u901f\u5c0e\u5165\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u7d50\u8ad6\uff1a\u5e0c\u671b\u4e4b\u5149\uff0c\u884c\u52d5\u6642\u523b<\/h4>\n\n\n\n<p>2025\u5e74\uff0c<strong>\u7cd6\u5c3f\u75c5\u5e79\u7d30\u80de\u7642\u6cd5<\/strong>\u5f9e\u5be6\u9a57\u5ba4\u8d70\u5411\u81e8\u5e8a\uff0c\u8b93\u300c\u529f\u80fd\u6027\u6cbb\u76521\u578b\u7cd6\u5c3f\u75c5\u300d\u6210\u70ba\u73fe\u5be6\u3002VX-880\u7b49\u5275\u65b0\u4e0d\u50c5\u6e1b\u5c11\u91dd\u982d\uff0c\u9084\u91cd\u5851\u751f\u6d3b\u3002\u7121\u8ad61\u578b\u62162\u578b\uff0c\u79d1\u5b78\u6b63\u5e36\u4f86\u300c\u8eab\u9ad4\u81ea\u5df1\u6551\u81ea\u5df1\u300d\u7684\u5947\u8e5f\u3002\u60a3\u8005\u5011\uff0c\u4fdd\u6301\u6a02\u89c0\uff0c\u8ffd\u8e64\u6700\u65b0\u7814\u7a76\u2014\u2014\u672a\u4f86\u5df2\u4f86\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-small-font-size\">References<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li class=\"has-small-font-size\"><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2506549\" target=\"_blank\" rel=\"noopener\">NEJM: Stem Cell\u2013Derived, Fully Differentiated Islets for Type 1 Diabetes (2025)<\/a><\/li>\n\n\n\n<li class=\"has-small-font-size\"><a href=\"https:\/\/investors.vrtx.com\/news-releases\/news-release-details\/vertex-announces-positive-results-ongoing-phase-12-study-vx-880\" target=\"_blank\" rel=\"noopener\">Vertex Pharmaceuticals: Positive Results from VX-880 Phase 1\/2 Study (ADA 2025)<\/a><\/li>\n\n\n\n<li class=\"has-small-font-size\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04786262\" target=\"_blank\" rel=\"noopener\">ClinicalTrials.gov: VX-880 FORWARD-101 Trial (NCT04786262)<\/a><\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading has-small-font-size\">\u514d\u8cac\u8072\u660e<\/h4>\n\n\n\n<p class=\"has-small-font-size\">\u672c\u6587\u57fa\u65bc\u516c\u958b\u79d1\u7814\u8cc7\u6599\u8207\u65b0\u805e\uff0c\u63d0\u4f9b\u6559\u80b2\u6027\u8cc7\u8a0a\uff0c\u4e26\u975e\u91ab\u7642\u5efa\u8b70\u3002\u7cd6\u5c3f\u75c5\u6cbb\u7642\u56e0\u4eba\u800c\u7570\uff0c\u8acb\u8aee\u8a62\u5c08\u696d\u91ab\u5e2b\uff08\u5982\u9999\u6e2f\u7cd6\u5c3f\u75c5\u5354\u6703\u8a8d\u8b49\u5c08\u5bb6\uff09\u8a55\u4f30\u500b\u4eba\u72c0\u6cc1\u3002\u6240\u6709\u6578\u64da\u622a\u81f32025\u5e7411\u6708\uff0c\u672a\u4f86\u8a66\u9a57\u7d50\u679c\u53ef\u80fd\u8b8a\u52d5\u3002\u4f5c\u8005\u8207xAI\u4e0d\u627f\u64d4\u4efb\u4f55\u91ab\u7642\u8cac\u4efb\u3002<\/p>\n\n\n\n<p><\/p>\n<div class=\"sws_supernormalaction\"><button on=\"tap:superwebshare-lightbox\" class=\"superwebshare_normal_button1 superwebshare-button-medium superwebshare-button-circle superwebshare_prompt superwebshare_button_svg\" style=\"color:#ffffff;background-color: #ffaa06;\" ><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" 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